![]() ![]() Although geographically widespread across tropical and subtropical malaria-endemic regions 2, 3, P. Plasmodium malariae is one of six Plasmodium species that commonly cause malaria in humans 1. malariae, and thus reflects a recent anthroponosis. brasilianum falls within the radiation of human P. malariae indicate that it resulted from the zoonotic transmission of an African ape parasite, reminiscent of the origin of P. Moreover, the levels and nature of genetic polymorphisms in P. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. A second ape-derived lineage is much more closely related to the third, human-infective lineage P. malariae-related sequences in wild and captive African apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central Africa. Using a novel approach to characterise P. The human parasite Plasmodium malariae has relatives infecting African apes ( Plasmodium rodhaini) and New World monkeys ( Plasmodium brasilianum), but its origins remain unknown. ![]()
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